Editors: Dr Mukul Kumar Baruah, Dr Rahul Kanti Nath & Dr Joyobrato Nath (2025)

ISBN: 97978-93-94174-62-7

Biofilm Formation Dynamics and Regulatory Pathways in Escherichia coli

Department of Microbiology, Techno India University, Tripura-799004, India

Escherichia coli is a Gram-negative bacillus, belonging to the family Enterobacteriaceae that commonly resides in the lower intestinal tract of human. It plays vital role in nutrient absorption but often can lead to infections such as gastroenteritis and urinary tract infections. Biofilm formation in E. coli is a highly regulated, multiphase process that allows them to adapt to diverse environments and survive under stress. This process involves four distinct phases, initiating with reversible surface adhesion, microcolony formation ensuring irreversible attachment, maturation and terminating with dispersion. Each of these phases is precisely controlled by dedicated networks that monitor environmental signals, cell density, and nutrients availability, enabling economic control over the production or repression of key regulatory molecules. Understanding E. coli biofilm and its regulatory network would provide critical insights in designing strategies to either combat infectious biofilms in clinics or to optimize biofilm designing in industrial bioprocess, agriculture and environmental management.

*Corresponding author; e-mail: ankurita.b@tiut.ac.in

Cite this Chapter: Pushpa Reang and Ankurita Bhowmik. 2025. Biofilm Formation Dynamics and Regulatory Pathways in Escherichia coli. In: Mukul Kumar Baruah, Rahul Kanti Nath and Joyobrato Nath (Eds.), Transdisciplinary Science: Mapping the Future of Research. Excellent Publishers, India. pp. 167-174. doi: https://doi.org/10.20546/978-93-94174-62-7_15