Development of Biogenic Nanomaterials and their Benign Applications pp 79-90
Editors: Dr. R. Balachandar
Dr. K. Ashok Kumar (2022)
ISBN: 978-93-94174-20-7
Chapter 7
Applications of Nanomaterial in Recombinant DNA Technology
1Department of Biotechnology, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai – 600 117, India
2Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur - 603203, India
Abstract
Nanomaterials have revolutionized various scientific and technological fields, including recombinant DNA technology, opening new possibilities for precise and efficient genetic engineering processes. This chapter explores the application of nanomaterials in recombinant DNA technology and its potential impact on plant biotechnology and tissue engineering. Nanoparticles, nanotubes, and nanowires are among the commonly used nanomaterials that offer unique properties at the nanoscale, making them suitable for targeted gene delivery and interaction with cellular components. By encapsulating and protecting DNA constructs, nanomaterials enhance stability and prevent degradation during delivery. They can also be modified to facilitate specific interactions, leading to improved cellular uptake and gene expression. The integration of nanomaterials with gene-editing tools like CRISPR-Cas9 enhances precision and efficacy in genetic modifications. Furthermore, nanotechnology-based genome editing shows promise in tissue engineering, enabling the regeneration of bone and neural tissues. This chapter also discusses challenges such as nanoparticle phytotoxicity and scale-up issues in plant gene editing. Despite these challenges, the use of nanomaterials in recombinant DNA technology offers remarkable potential for advancements in medicine, agriculture, and environmental remediation. It opens up new avenues for targeted drug delivery, genetically modified crop development, and the creation of functional artificial tissues. Continued research and development in this field hold exciting prospects for the future of biotechnology and medicine, ultimately benefiting humanity and the environment.
Keywords
Agriculture, CRISPR-Cas9, genome editing, medicine, tissue engineering
Cite this Chapter: Muthusamy Suganthi, M. Priyadharshini, N. Yokesh, Palanisamy Senthilkumar and Gopalakrishnan Abirami. 2023. Applications of Nanomaterial in Recombinant DNA Technology. In: R. Balachandar and K. Ashok Kumar (Eds.), Development of Biogenic Nanomaterials and their Benign Applications. Excellent Publishers, India. pp. 79-90. doi: https://doi.org/10.20546/978-93-94174-20-7_7
